Glanzmann′s thrombasthenia and molecular mimicry
نویسندگان
چکیده
منابع مشابه
Molecular mimicry
EditoriAL EditoriAL Over the course of evolution, microorganisms have developed innovative survival strategies to thrive in their hosts. 1 The human body is home to many species of bacteria, viruses, fungi, and other invertebrate parasites. Some of these organisms that live and thrive in humans are com-mensals and are harmless. They may be also beneficial to the host as they provide certain nut...
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For more than three decades, molecular mimicry has been considered a contributing factor in viral pathogenesis. The phenomenon comes about when viral antigens share epitopes with host cell proteins. Because tolerance is thought never to be complete, the mimicking microbe can induce anti-self antibodies, a state of autoimmunity, with resulting immunopathogenesis. This mode of attack seems preemi...
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Immune thrombocytopenia is a common complication of infection with the human immunodeficiency (HIV)1 and hepatitis C (HCV)2 viruses. In previous works, the authors showed that many patients with HIVassociated thrombocytopenia have autoantibodies that recognize a restricted peptide sequence (GPIIIa49-66) in platelet membrane glycoprotein IIIa (GPIIIa) and can be recovered from patient plasma in ...
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Most experts believe that multiple sclerosis is an autoimmune disease in which T cells recognize and attack components of the axonal myelin sheath and other features of the central nervous system, destroying myelin and the underlying axon. Although self-reactive T cells are present in the immune system of people with multiple sclerosis, they are also found in a quiescent state in perfectly heal...
متن کاملMolecular mimicry in autoimmune disease.
The origins of autoimmune disease are multifactorial. Environmental factors and a genetic predisposition result in tissue injury caused by autoreactive T cells or antibodies. Usually a single organ or individual cell type is aVected in the absence of gross abnormalities of the immune system. Autoimmune diseases tend to have long, asymptomatic prodromal periods and the initiating events leading ...
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ژورنال
عنوان ژورنال: Indian Journal of Human Genetics
سال: 2010
ISSN: 0971-6866
DOI: 10.4103/0971-6866.64942